0306 Normative Data of Cyclic Alternating Pattern across the Lifespan

Abstract Introduction Cyclic alternating pattern (CAP) is a marker of sleep instability, and neuroplasticity. Slow wave has been described as stable period, CAP can be funcional delta sleep. The aim this review was to evaluate the normative data parameters according aging process in healthy subjects. Methods Two authors independently searched databases using PRISMA guidelines through systematic meta-analysis. Subgroup analysis tests for heterogeneity were conducted. Descriptive statistics used variables. Meta-analyses performed by Comprehensive Meta- Analysis software. Data extracted from tables provide Results We found evolution rate across lifespan. Squares diamond represent mean while bars range between 95% CI values each age range. analysed 168 individuals analyses. Scoring begin at 3 months life, when K-complexes, bursts, or spindles recognized. Rate increased with age, mainly during first 2 years then decreased adolescence, elderly. A1 subtype high school-aged children slow-wave (SWS). Our meta-analysis registered lowest infants younger than old highest Conclusion NREM connected brain maturation.The depth, especially SWS. These disorders treatment goal. may reflect neurodiversity endophenotype human cronobiotypes. Further studies about subtypes are needed. Support (If Any)